| 喷昔洛韦缓释微球在Beagle犬体内的生物等效性研究 |
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| 引用本文： | 陈俊萍,李向阳.喷昔洛韦缓释微球在Beagle犬体内的生物等效性研究[J].青海医药杂志,2012,42(6):7-10. |
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| 作者姓名： | 陈俊萍 李向阳 |
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| 作者单位： | 1. 青海省西宁市第二人民医院 810003
2. 青海大学医学院 810001 |
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| 摘 要： | 目的:建立犬血浆中喷昔洛韦的高效液相色谱测定方法,并研究喷昔洛韦缓释微球在犬体内的药动学和生物利用度。方法:12只犬随机分为两组,每组6只,分别口服给予喷昔洛韦缓释微球和普通片剂375mg后,采用高效液相色谱法检测血药浓度。结果:喷昔洛韦缓释微球和普通片剂的达峰时间(Tmax)分别为(4.70±0.82)h和(1.83±0.27)h,达峰浓度(Cmax)分别为(2.62±1.14)μg.mL-1和(4.50±0.763)μg.mL-1,半衰期(T1/2)分别为(20.256±0.436)h和(6.865±0.607)h,曲线下面积(AUC0-8)为(25.34±6.33)μg.h.mL-1和(26.77±4.95)μg.h.mL-1。结论:喷昔洛韦缓释微球具有明显的缓释特性。
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| 关 键 词： | 喷昔洛韦缓释微球 药动学 生物等效 高效液相色谱法 |
Pharmacokinetics and Bioequivalence of Penciclovir Sustained - release Pellets in Beagle Dog |
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| Chen Junping
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Li Xiangyang.Pharmacokinetics and Bioequivalence of Penciclovir Sustained - release Pellets in Beagle Dog[J].Qinghai Medical Journal,2012,42(6):7-10. |
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| Authors: | Chen Junping Li Xiangyang |
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| Institution: | 1 The Second People’s Hospital of Xining City(810003) 2 Qinghai University Medical School(810001) |
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| Abstract: | Objective:To establish an RP-HPLC method to study the pharmacokinetics and bioequivalence of penciclovir sustained-release pellets in beagle dog.Methods:12 beagle dogs were divided into 2 groups each 6 animals,group I was given 375mg penciclovir sustained-release pellets and the group II was administrated penciclovir tablets of 375mg.The plasma level of penciclovir was determined by HPLC.Results:The main pharmacokinetic parameters of penciclovir sustained-release pellets and tablets were Tmax(4.70 ± 0.82) h and(1.83 ± 0.27) h,Cmax(2.62 ± 1.14) μg·mL-1and(4.50 ± 0.763) μg·mL-1,T1/2(20.256± 0.436) h and(6.865±0.607)h,AUC0~8(25.34 ± 6.33) μg·h·mL-1 and(26.77 ± 4.95) μg·h·mL-1,respectively.Conclusions:An obvious characteristic of sustained release of penciclovir sustained-release pellets was shown through the concentration-time curves in beagle dog. |
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| Keywords: | Penciclovir sustained-release pellets Pharmacokinetics Bioequivalence HPLC |
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