盐酸戊乙奎醚注射液联合阿托品治疗急性有机磷中毒的临床效果

目的研究盐酸戊乙奎醚注射液联合阿托品治疗急性有机磷中毒的临床效果。方法将我院收治的68例急性有机磷中毒患者按照治疗方法的不同分为对照组(34例,阿托品)与研究组(34例,盐酸戊乙奎醚注射液联合阿托品)。比较两组的治疗效果。结果治疗1、2 d后,两组胆碱酯酶活性均升高,且研究组高于对照组(P<0.05)。研究组阿托品化时间、中枢神经症状消失时间、毒蕈碱样(M)症状消失时间、住院时间、胆碱酯酶活性恢复70%以上时间、中毒症状维持时间均短于对照组,用药次数少于对照组(P<0.05)。两组患者不良反应总发生率无显著差异(P>0.05)。结论盐酸戊乙奎醚注射液联合阿托品在急性有机磷中毒治疗中应用效果显著,且安全性高,值得推广应用。

Clinical effect of penehyclidine hydrochloride injection combined with atropine in the treatment of acute organophosphorus poisoning

Objective To study the clinical effect of penehyclidine hydrochloride injection combined with atropine in the treatment of acute organophosphorus poisoning. Methods A total of 68 patients with acute organophosphorus poisoning admitted in our hospital were divided into control group(34 cases, atropine) and study group(34 cases, penehyclidine hydrochloride injection combined with atropine) according to the different treatment methods. The treatment effects of the two groups were compared. Results At l and 2 day after treatment, the cholinesterase activity in both groups increased, and those in the study group were higher than the control group(P<0.05). The atropinization time, the disappearance time of central nervous system symptoms and muscarinic(M) symptoms, hospitalization time, the recovery time of cholinesterase activity more than 70% and the maintenance time of poisoning symptoms in the study group were shorter than those in the control group, and the medication time in the study group was fewer than that in the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P >0.05). Conclusion Penehyclidine hydrochloride injection combined with atropine in the treatment of acute organophosphorus poisoning has a significant effect and high safety, which is worthy of popularization and application.