血清尿酸、肌酐及血脂水平检测在双相情感障碍患者中的临床意义

目的研究血清尿酸(UA)、肌酐(CRE)、血脂水平检测在双相情感障碍患者中的临床意义,为双相情感障碍的临床诊治提供新思路。方法选择我院2016年8月至2018年8月收治的98例双相情感障碍患者为双相情感障碍组,包括躁狂发作患者60例(躁狂发作组)及抑郁发作患者38例(抑郁发作组);选择同时期来我院健康体检者50例作为健康对照组。对双相情感障碍组及健康对照组患者的空腹血清UA、CRE、甘油三脂(TG)及总胆固醇(CHO)水平进行比较。结果双相情感障碍组、躁狂发作组及抑郁发作组血清UA、CRE、TG及CHO水平均明显高于健康对照组,差异具有统计学意义(P<0.05)。Pearson相关分析结果显示,双相情感障碍患者中,血清UA水平与CRE、TG及CHO水平呈正相关(P<0.05)。结论相比于健康人员,双相情感障碍患者血清UA、CRE、TG及CHO水平升高,临床可将以上指标的检测应用于双相情感障碍患者的筛查及病情监测。

Clinical significance of the detection of levels of serum uric acid,creatinine and lipid in patients with bipolar affective disorder

Objective To study the clinical significance of the detection of levels of serum uric acid (UA),creatinine (CRE) and lipid in patients with bipolar affective disorder,and find new ideas for clinical diagnosis and treatment of bipolar affective disorder.Methods A total of 98 patients with bipolar affective disorder admitted in our hospital from August 2016 to August 2018 were selected as bipolar affective disorder group,including 60 patients with manic episode (manic episode group) and 38 patients with depression episode (depression episode group).Fifty cases of health examination in the same period were selected as the healthy control group.The levels of fasting serum UA, CRE,triglyceride (TG) and total cholesterol (CHO) in patients of the bipolar affective disorder group and healthy control group were compared and analyzed.Results The serum levels of UA, CRE,TG and CHO in the bipolar affective disorder group,manic episode group and depression episode group were higher than those in the healthy control group,and the differences were statistically significant (P<0.05).The results of Pearson correlation analysis showed that the serum UA level was positively correlated with the levels of CRE,TG and CHO in patients with bipolar affective disorder (P<0.05).Conclusion Compared with healthy people,the serum UA,CRE,TG and CHO levels in patients with bipolar affective disorder increased.The above indexes can be used in clinical screening and disease monitoring of patients with bipolar affective disorder.