| Distribution of SP receptor in the auditory centre of brainstem and inthe medial geniculate body of guinea pigs |
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| 引用本文： | 邱建华,王锦玲,施际武,李元庆,刘顺利. Distribution of SP receptor in the auditory centre of brainstem and inthe medial geniculate body of guinea pigs[J]. 中国人民解放军军医大学学报, 1998, 0(2) |
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| 作者姓名： | 邱建华 王锦玲 施际武 李元庆 刘顺利 |
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| 作者单位： | Departments of Otorhinolaryngology and Anatomy，Xijing Hospital，Fourth Military Medical University，Xian，710032 |
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| 摘 要： | SubstanceP(SP)hasbeenaffirmedasaprimaryafferentsensoryneurotransmitter.Intheauditorysystemofthemammal,SPisalsowidelydistributed.YlikosikietallljreportedthatSPmightbeaprimaryafferentneurotransmitterormodulatorinrabbitcochlea.WehavereportedthedistributionofSPandsubstancePreceptor(SPR)inthecochleaofguineapigsL'j.ButthereisnoreportaboutthedistributionofSPandSPRintheauditorycentreandmedialgenicularbodyofguineapigs.Inthispaper,wedescribethedistributionofSPR--positiveneuronsandfibersintheco…
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Distribution of SP receptor in the auditory centre of brainstem and in the medial geniculate body of guinea pigs |
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| Qiu Jianhua,Wang Jiming,Shi Jiwu,Li Yunqing, Lin Shunli. Distribution of SP receptor in the auditory centre of brainstem and in the medial geniculate body of guinea pigs[J]. Journal of Medical Colleges of PLA(China), 1998, 0(2) |
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| Authors: | Qiu Jianhua Wang Jiming Shi Jiwu Li Yunqing Lin Shunli |
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| Abstract: | Objective: To investigate the distribution of substance P receptor (SPR) in the brainstem auditorycentre and medial geniculate body (MGB) of guinea pigs. Methods: Rabbit antiserum against SPR, immunohistochemical method and glucose-oxidase-DAB-nickle technique were used in this study. Results:SPR-positiveneurons, fibers and terminals were distributed widely in the cochlear nucleus, superior olive complex,inferiorcolliculus and MGB. In the cochlear nucleus, SPR-positive neurons were distributed mainly in the ventralcochlear nucleus (VCN). SPR-positive products were located predominately on the cell membrane. The density of positive terminals in the dorsal cochlear nucleus (DCN) was higher than that in the ventral cochlear nucleus. The distribution pattern of SPR-positive products in the superior olive complex had distinct characteristics. SPR-positive fibers, terminals and neurons were also found, but the number of positive neurons wasfewer. The density of SPR-positive fibers and terminals in the MGB was quite high. Conclusion:SP may participate in transmitting sound messages in brainstem auditory centre and MGB of the guinea pig. |
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| Keywords: | substance P receptor immunohistochemistry brainstem auditory centre guinea pig |
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