头痛宁胶囊治疗偏头痛的疗效评价及其对血小板和血液流变学的影响

目的:观察头痛宁胶囊治疗偏头痛患者的疗效及其对血小板、血液流变学指标的影响.方法:将336例偏头痛患者随机分为两组:头痛宁胶囊治疗组168例,给予头痛宁胶囊口服,每次3粒,1日3次;西比灵对照组168例,给予西比灵胶囊口服,每次1粒,1日2次.疗程均为2周.观察两组患者的疗效和血小板、血液流变学指标的变化.结果:治疗组和对照组总有效率分别为89.9％,72.6％,治疗组的疗效显著优于对照组(P＜0.05);治疗组治疗后血小板及血液流变学各项指标改变与治疗前比较差异均有显著性(P＜0.05或P＜0.01).结论:头痛宁胶囊能抑制血小板聚集,降低全血黏度,改善患者血液循环,治疗偏头痛安全、有效.

Therapeutic Effect of Toutongning Capsule in Treatment of Patients with Migraine and its Effects on Blood Platelet and Hemorrheological Parameters

Objective: To observe the therapeutic effects of Toutongning capsule in the treatment of patients with migraine and its effects on blood platelet and hemorrheological paramters. Method: Three hundredend thirty-sixty patients with migraine were divided randomly into two groups: Toutongning treatment group (treatment group)168 cases (giving Toutongning capsule, 3 capsules each time,3 times a day), Xibiling treatment group(contral group) 168 cases(giving Xibiling capsule, one capsule each time, 2 times a day).A treatment course is composed of 2 weeks. The therapeutic effects and the changes of blood platelet and hemorrheological paramters were observed in two group. Result: The total effective rates of the treatment group and the contral group were 89.9% and 72.6%,respectively(P<0.05).The changes of blood platelet and hemorrheological paramters were significantly higher after teratment than those before teratment in teratment group(P<0.05 or P<0.01). Conclusion: Toutongning capsule can restrain the blood platelet gather,decrease whole blood viscosity, improve the blood circulation,and which is safe and effective in treating Patients with Migraine.