妊娠期脂质过氧化作用与围产儿预后的关系

目的 探讨脂质过氧化(LPO)作用与围产儿预后的关系。方法 选择正常晚期妊娠妇女102例和妊娠期肝内胆汁瘀积症(ICP)患者126例。分别测定LPO和红细胞超氧化物歧化酶(RBC-SOD)活性;比较新生儿出生体重、Apgar评分和羊水状况。结果 ICP组母血LPO和RBC-SOD均明显高于对照组,二者呈显著正相关。在ICP组,宫内生长受限(IUGR)、新生儿窒息和羊水异常时,脐血LPO浓度均明显增高,而脐血RBC-SOD活性均明显下降。脐血LPO与新生儿出生体重和Apagr评分呈明显负相关。结论 LPO与ICP围产儿不良预后密切相关。

Investigation of relationship between lipid peroxidation of intrahepatic cholestasis during pregnancy and the prognosis of fetus and neonates

Objective To investigate the relationship of Lipid Peroxidation (LPO) and perinatal prognosis of intrahepatic cholestasis during pregnancy (ICP). Methods Activity of LPO and Red Blood Cell Super-Oxide Dismutase (RBC-SOD) of 126 ICP women and 102 non-ICP control women were examined separately, and the birth weight. Apgar score and amniotic fluid status of newborns were compared between the two groups. Results LPO and RBC-SOD, with significantly positive association, of ICP mothers were significantly higher than those of control mothers. In ICP group, those with intra-utera growth retardation (IUGR), neonatal asphyxia and amniotic fluid abnormality have remarkably increased LPO concentration and deceased cord blood RBC-SOD . It shows significantly negative association between neonatal birth weight, Apgar score and cord blood LPO concentration. Conclusion LPO is tightly related to perinatal prognosis of ICP.