天山雪莲培养物对小鼠免疫功能的影响

目的：探讨天山雪莲培养物的免疫作用。方法：小鼠灌胃给予天山雪莲培养物,剂量分别为75、150、300mg/kg,连续给药7天,观察天山雪莲培养物对小鼠碳粒廓清、对DNCB致小鼠迟发型超敏反应和对小鼠溶血素形成的影响。结果：与空白给药组相比,天山雪莲培养物（150mg/kg）对非特异性免疫功能有一定抑制作用;300mg/kg的天山雪莲培养物对小鼠迟发超敏反应有抑制作用,对绵羊红细胞所致小鼠特灵性抗体生成有增强作用。结论：天山雪莲培养物具有调节免疫功能作用。

Effects of Saussurea Involucrata Culture on Mouse Immune Function

Objective:The tissue culture of Saussurea involucrata has been studied for the protection of immune function activities in animal models in our research.Methods: The tissue culture of S.involucrata at the doses of 75,150 and 300mg/kg were given to mice by intragastric administration,successive medication for 7 days,and then the effects of S.involucrata were investigated in mice by carbon clearance rate,DNCB induced delayed hypersensitivity and serum hemolysin formation.Results: The tissue culture of S.involucrata at the doses of 150mg/kg i.g.,for 7 days could inhibit the non-specificity of immune function in mice.At the doses of 300mg/kg i.g.,for 7 days it could have significantly inhibitory effect on delayed hypersensitivity in mice and increase the humoral immunity activity in mice.Conclusion: The tissue culture of S.involucrata had the protection effect on immune function activities.