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Patent foramen ovale and paradoxical embolism can never be wiped out of our sight.

??Abstract??The patent foramen ovale (PFO) persists during fetal life and approximately 1 of every 4 adults.In recent years??PFO has been implicated in the etiology of cryptogenic stroke secondary to paradoxical embolism??migraine headache??platypneaorthodeoxia syndrome and neurologic decompression illness.This article focuses on the relationship between PFO and PDE??the current research status and treatment of PFO-related syndromes??so as to further understand PFO and PDE??thus proposing theoretical evidence for the treatment of PFO-related syndromes.