| 银杏内酯对大脑中动脉阻塞大鼠脑内iNOS表达的影响 |
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| 引用本文： | 任俊,贾正平,张汝学,马慧萍. 银杏内酯对大脑中动脉阻塞大鼠脑内iNOS表达的影响[J]. 中成药, 2004, 26(12): 1037-1039 |
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| 作者姓名： | 任俊 贾正平 张汝学 马慧萍 |
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| 作者单位： | 兰州军区兰州总医院,全军临床药理基地,甘肃,兰州,730050 |
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| 摘 要： | 目的:观察银杏内酯对大脑中动脉阻塞大鼠脑内诱导型一氧化氮合酶(iNOS)表达的影响.方法:采用颈内动脉线栓法制备大鼠大脑中动脉阻塞模型,对使用银杏内酯、尼莫地平、银可络的大鼠进行神经行为评分,筛选造模成功大鼠进行SABC染色.结果:模型组缺血侧脑组织iNOS大量表达,银杏内酯高、中剂量给药组缺血侧脑组织iNOS阳性细胞表达明显减少.结论:银杏内酯可抑制缺血脑组织iNOS的表达,具有减轻缺血后脑损害的作用.
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| 关 键 词： | 银杏内酯 脑缺血 诱导型一氧化氮合酶 大鼠 |
| 文章编号： | 1001-1528(2004)12-1037-03 |
Influence of ginkgolides on expression of iNOS in MCAO rats |
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| REN Jun,JIA Zheng ping,ZHANG Ru xue,MA Hui ping. Influence of ginkgolides on expression of iNOS in MCAO rats[J]. Chinese Traditional Patent Medicine, 2004, 26(12): 1037-1039 |
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| Authors: | REN Jun JIA Zheng ping ZHANG Ru xue MA Hui ping |
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| Abstract: | AIM: To study the influence of ginkgolides on expression of inducible nitric oxide synthase (iNOS) in rats. METHODS: Middle cerebral artery occlusion(MCAO) model was induced by ligating internal carotid artery of Sprague Dawley(SD) rats.In this model,the behavioral deficits performance of SD rats was analyzed after given ginkgolides and nimo dipin, respectively, and iNOS gene expression changes in MCAO group were investigated. RESULTS:The expression of iNOS was increased in MCAO models and inhibited in ginkgolides groups. CONCLUSION:Ginkgolides have inhibitive efficacy of iNOS on cerebral ischemia and can reduce brain damage. |
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| Keywords: | ginkgolides cerebral ischemia iNOS rat |
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