老年人轻度认知功能损害的神经心理测验研究

目的；用神经心理测验研究老年人轻度认知功能损害的特点。方法；为横断面比较研究。研究对象分为两组，即有轻度认知功能损害的老年人（ＭＣＩ组）和认知功能正常的老年人（对照组，ＮＣ组）。以世界卫生组织老年认知功能介成套神经心理测验（ＷＨＯ－ＢＣＡＩ）为主要研究工具。

Neuropsychological attributes of mild cognitive impairment in the elderly

Objective: To examine the characteristics of mild cognitive impairment of elderly subjects with neuropsychological tests to enable early detection of Alzheimer disease. Method: 27 subjects with mild cognitive impairment (MCI) and 33 normal controls (NC) were recruited. The World Health Organisation battery of cognitive assessment instruments for elderly (WHOBCAI) was adopted for cognitive assessment of the studied subjects. Results: The mean total scores of minimental status examination (MMSE) were 24221 for MCI and 28711 for NC. The mean total scores of activity of daily living (ADL) were 24918 for MCI and 21413 for NC. The results of WHOBCAI tests demonstrated that there were significant differences between the two groups in most of the subtests including auditory verbal learning, delayed recall, naming, verbal fluency, sorting, minitoken, trail making, psychomotor testing, visual recognition, reasoning and semantic association, and spatial construction. Among the significant variables, trail making B, minitoken, psychomotor testing, visual reasoning and semantic association finally entered into the standardized canonical discriminant functions. Conclusion: Our study suggest that trail making B, minitoken, psychomotor testing, visual reasoning and semantic association can discriminate MCI from normal controls and are thus sensitive tools in early detection of Alzheimer disease.