肺癌中p53蛋白的表达及其临床病理意义

目的：探讨肺癌中ｐ５３蛋白表达与临床病理的关系。方法：应用免疫组织化学ｓ－ｐ法对１２９例肺癌组织标本进行ｐ５３蛋白检测。结果：ｐ５３蛋白阳性表达率为５２．７％，其表达与组织学分型分级无关，仅在腺癌组内与淋巴结有无癌转移有关（Ｐ〈０．０５），半年以内死亡组与５年以上生存组之间有显著性差异Ｐ〈０．０５，结论，ｐ５３蛋白表达能够反映肿的生物学特性，并可作为评估肿瘤预后的有效指标。

EXPRESSION OF P 53 PROTEIN IN LUNG CANCER AND ITS CLINICAL PATHOLOGICAL SIGNIFICANCE

Objective: To study the expression of p53 protein in lung cancer and its relationship to clinical pathological factors. Methods: Expression of p53 protein was detected with immunochemistry in 129 cases of lung cancer. Results: Positive rate of p53 protein was 52.7%.The positive rate was not correlated with histological type and grade,only in adenocarcinoma the expression of p53 protein was correlated with lymph node metastasis ( P <0.05).Between the death in 0.5 year and the live over 5 years,the positive rate of p53 showed significant difference( P <0.05). Conclusion: Expression of p53 protein is related to biological behaviors of lung cancer and has important effect on predicting the prognosis of lung cancer patients.