白细胞介素-2对慢性活动性肝炎HBV血清学标志的影响

现已知白细胞介素-2(IL-2)对T细胞、NK细胞、B细胞的功能及干扰素的产生均有作用。本文应用IL-2治疗HBV所致的慢性活动性肝炎(CAH)患者10例,以观察其对HBV复制指标的动态变化和免疫效果。结果显示:HBeAg阴转4例(4/10);IgM-抗HBc阴转3例(3/10),且与HBeAg阴转相一致;在检测HBV-DNA的3例中有2例阴转(2/10)。与对照组相比,其中HBeAg阴转率有显著性差异(P<0.05),但HBsAg无1例阴转。上述结果提示IL-2对HBV的复制确有一定的抑制作用,至于其对HBV确切的清除作用尚需要更多病例作临床验证才能作出比较正确的疗效评价。

EFFECTS OF HUMAN INTERLEUKIN-2 ON HBV SEROLOGlCAL MARKERS IN PATIENTS WITH CHRONIC ACTIVE HEPATITIS B.

Human interleukin-2 ( IL-2 ) promotes the proliferations of human T cell, NK cell, B cell and induced interferon production. This paper reports the results of treatment using IL-2 in 10 cases of chronic active hepatitis B ( CAH ) . HBeAg became negative in, 4 cases, IgM anti-HBc became negative in 3 cases, and HBV-DNA became negative in 2 of the 3 cases after this treatment. There was a significant difference of percentage of seroconversion from HBeAg postive to HBeAg negative between the treatment group and control group ( P<0.05 ). In all cases HBsAg was still positive. These results indicate that the IL-2. may transiently suppress the replication of HBV. To verify the effect of IL-2 on the eradication of HBV, more clinical treatment and observation need to be performed.