Ⅰ型生长因子受体家族在非小细胞肺癌中的表达及其预后价值的研究

目的 探讨Ⅰ型生长因子受体家族在非小细胞肺癌（NSCLC）组织中异常表达的临床意义及预后价值。方法 用免疫组化法研究了58例NSCLC组织中c-erbB-1、c-erbB-2、c-erbFk3、c—erbB-4蛋白的表达。结果 NSCLC组织中，C-erbB-1、C-erbD-2、c—erbB-3蛋白表达高于正常组织，过表达率分别为62．07％、60．34％和41．38％。C-erbB-4表达率为63．85％，显著低于正常组织（P=0．03）。c—erbB-1蛋白过表达与PCNA指数呈正相关（r=0．248，P〈0．05）；c-erbB-2蛋白过表达与肿瘤的分化程度呈负相关（r=0．29，P〈0．05），c-erbB-2和C-erbB-3蛋白的过表达，及二者的共过表达，与TNM分期有密切关系（P〈0．01）；C-erbB-4蛋白表迭趋向于高分化肿瘤（P〈0．01）。C-erbB-2蛋白过表达及其与c—erbB-3蛋白共过表达显示预后不良（P〈0．01）。结论 Ⅰ型生长因子受体家族在NSCLC的发生、发展中起着重要的作用，并有助于判断预后。

Research of expression and prognostic value of type I growth factor receptor family protein in non small cell lung cancer

Objective To explore the clinical significance of type I growth factor receptor family in non small cell lung cancer(NSCLC).Methods Expressions of c-erbB-1,c-erbB-2,c-erbB-3,c-erbB-4 protein were detected in 58 samples of NSCLC by immunohistochemistry.Results Four oncogenes from type I growth factor receptor family were all detected abnormal protein expression in NSCLC.C-erbB-1,c-erbB-2,c-erbB-3 were overexpressed and their overexpressed rates were(62.07)%,(60.34)%,and(41.38)%,respectively.C-erbB-4 was always under expression(P=(0.03)),compared to normal lung tissues in NSCLC and its expression rate was(63.85)%.Overexpression of c-erbB-1 protein showed positive correlation to PCNA index(P<(0.05)).Overexpression of c-erbB-2 protein showed more poorly differentiated NSCLC and a negative prognostic value by survival analysis(P<(0.01)).C-erbB-2 and c-erbB-3 protein had higher overexpression rate in advanced NSCLC than early stages(P<(0.01)).C-erbB-4 tended to express in well-differentiated NSCLC(P<(0.05)).Co-overexpression between c-erbB-2 and c-erbB-3 was associated with TNM stage(P<(0.01)).And it could be a marker of prognosis(P<(0.01)).Conclusion Type I growth factor receptor family may play important roles in the oncogensis and development of NSCLC.And they could serve as important prognostic reference markers in NSCLC.