| 早白发病遗传方式的观察 |
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| 作者单位： | Zhang Lian Zhu，Che De Chai，Ni Chun Juan |
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| 摘 要： | 作者对１０６２０名初中生ＰＣＤ的发病情况进行群体调查，共检出ＰＣＤ患者１２０１例，群体发病率为１１．３０％，男女发病率为１１．８０％和１１．６４％。并用不完全确定法对４８例ＰＣＤ患者一级亲属的发病情况进行调查，一级亲属共２５０人，其中ＰＣＤ患者１２４人，发病率为４９．６０％，男女发病率为４９．５９％和４９．６０％。经Ｘ２检验，系谱分析，Ｓｍｉｔｈ法分离分析及Ｐｅａｒｓｏｎ法比值的吻合性分析，结果表明ＰＣＤ符合常染色体显性遗传方式。
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| 关 键 词： | 早白发病；常染色体显性遗传 |
Observation of the Inheritance Modeof Prematature Canities DiseaseDepartment of Biology |
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| Zhang Lian Zhu,Che De Chai,Ni Chun Juan. Observation of the Inheritance Modeof Prematature Canities DiseaseDepartment of Biology[J]. Journal of Changzhi Medical College, 1994, 0(1) |
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| Authors: | Zhang Lian Zhu Che De Chai Ni Chun Juan |
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| Abstract: | 1201cases Prematature Canities Disease (PCD) were determined in 10620pupils junior of middle school. The population incidence rate of PCD is 11.30%, 11. 80% inmale and 10. 64% in female. We also studied the first degree relatives (250) of 48 patientsin the 1201 PCD by using incomplete astertainment method 124 (49. 60%) suffered PCD,49. 5 % in male and 49. 60% in female. Analysis were mede by X2 teat, pedigree analysis,Smith's segregation method and Pearson's method of conformable, specific value. The results shwoed that PCD may be a kind of autosomal dominent inheritance disease. |
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| Keywords: | : Prematature Canities Disease (PCD) Autosomal Dominant Inheritance(AD) |
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