Enhanced affective aggression in genetically bred hypercholinergic rats |
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| Authors: | O Pucilowski B Eichelman D H Overstreet A H Rezvani D S Janowsky |
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| Affiliation: | Skipper Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill. |
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| Abstract: | Affective aggression was studied in pairs of Flinders Sensitive Line hypercholinergic rats (FSL) and Flinders Resistant Line (FRL) rats in shock-induced and apomorphine-induced fighting tests. FSL rats were significantly more aggressive in both tests. They had higher pain threshold, assessed by the jump-flinch method, than FRL rats. It is concluded that genetically developed cholinergic system supersensitivity has resulted in enhanced responsiveness to stimuli eliciting affective aggression. |
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