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| 五味保肝丸对急性肝损伤动物模型的作用 | |
| 引用本文： | 张伟,谢旭善,于爽,孙晶,曹璐璐,杨一丁,李德爱,李胜刚.五味保肝丸对急性肝损伤动物模型的作用[J].齐鲁医学杂志,2011,26(3):219-221,224. |
| 作者姓名： | 张伟 谢旭善 于爽 孙晶 曹璐璐 杨一丁 李德爱 李胜刚 |
| 作者单位： | 1. 青岛市海慈医疗集团,山东青岛,266033 2. 青岛市市立医院 3. 青岛市药检所 |
| 摘 要： | 目的探讨五味保肝丸对大鼠急性四氯化碳(CCl4)肝损伤的保护作用。方法将60只Wistar大鼠随机分成6组,每组10只。正常对照组、模型对照组灌胃给予20 g/L羧甲基纤维素钠溶液,联苯双酯组灌胃给予10 g/L联苯双酯混悬液,五味保肝丸高、中、低3个剂量组分别灌胃给予0.315 00、.157 5和0.078 8 kg/L五味保肝丸混悬液,各组给药量均为20 mL/kg,每日灌胃1次,连续7 d。末次给药2 h后,除正常对照组大鼠腹腔注射等量生理盐水,其余5组均腹腔注射CCl4原液1 mL/kg。检测各组大鼠血清中谷丙转氨酶(ALT)和谷草转氨酶(AST)活性,肝组织匀浆中超氧化物歧化酶(SOD)、丙二醛(MDA)含量,观察肝脏组织病理学变化情况。结果与模型对照组比较,五味保肝丸高、中剂量组血清中ALT活性降低,肝组织匀浆MDA含量降低,差异均有显著性(F=3.883、6.943,q=3.578～4.553,P<0.05);但AST、SOD的含量差异无显著性(P>0.05)。结论五味保肝丸对急性CCl4肝损伤大鼠的肝组织具有保护作用。 |
| 关 键 词： | 五味保肝丸 肝损伤 大鼠 Wistar |
EFFECT OF WUWEIBAOGANWAN ON RAT MODELS OF ACUTE HEPATIC DAMAGE |
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| ZHANG WEI,XIE XU-SHAN,YU SHUANG,SUN JING,CAO LU-LU,YANG YI DING,LI DE-AI,LI SHENG-GANG.EFFECT OF WUWEIBAOGANWAN ON RAT MODELS OF ACUTE HEPATIC DAMAGE[J].Medical Journal of Qilu,2011,26(3):219-221,224. | |
| Authors: | ZHANG WEI XIE XU-SHAN YU SHUANG SUN JING CAO LU-LU YANG YI DING LI DE-AI LI SHENG-GANG |
| Institution: | ZHANG WEI,XIE XU-SHAN,YU SHUANG,SUN JING,CAO LU-LU,YANG YI-DING,LI DE-AI,LI SHENG-GANG (Qingdao Haici Medical Group,Qingdao 266033,China) |
| Abstract: | Objective To investigate the protection of Wuweibaoganwan(WWBGW)-traditional Chinese medicine-onacute hepatic damage in rats caused by carbon tetrachloride(CCl4). Methods Sixty Wistar rats were evenly randomized to six groups: normal control(NC),model control(MC) group,bifendate group,high-,medium-,and low-dose WWBGW group.To those in NC and MC group,20 g/L CMC-Na solution was given;those in bifendate group,treated with 10 g/L bifendate suspl;those in high-,medium-,and low-dose WWBGW group,were treated with... |
| Keywords: | Wuweibaoganwan hepatocytes injury rats Wistar |
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