利血平和帕吉林对大鼠脑单胺递质含量的联合作用

大鼠ip利血平2mg/kg后1-24h,NE,DA,5-HT均显著下降(p<0.05-p<0.001),5-HIAA则显著升高(p<0.001)。ip帕吉林60mg/kg后1-24h,NE,DA,5-HT均显著升高(p<0.01-p<0.001),5-HIAA则在1-2h内显著下降(p<0.01),4-24h无明显变化。同时使用两药时,对鼠脑NE和DA的影响均呈拮抗作用,对5-HT仅表现帕吉林的作用。帕吉林对利血平化鼠的NE,DA无影响,但可使5-HT升至正常水平;利血平对帕吉林化鼠递质的变化无影响。两药合用对递质的影响表现为拮抗或单一作用,未见递质翻转现象。

Combined effect of reserpine and pargyline on contents of monoamine-transmitters in rat brains

Respective and combined effects of reserpine and pargyline on monoamine transmitters were studied in rat brains fluorospectrophotometri-cally.Reserpine and pargyline caused opposite effects on monoamine-transmitters in rat brains. The levels of norepineph-rine (NE), dopamine (DA) and serotonin (5-HT)decreased significantly but the level of 5-hydroxyindoleacetic acid (5-HIAA) increased significantly at all time intervals tested betweed 1 - 24 h after administration of reserpine. The levels of NE, DA, and 5-HT increased significantly at all time intervals tested between 1 -24 h after administration of pargyline; but the level of 5-HIAA decreased significantly only in the first and second hour. there was no changeat any other time. After administration of reserpine and pargyline together at the same time, the levels of NE and DA did not change significantly, but the level of 5-HT was the same as in rats treated by pargyline alone. The combined effects was antagonism. Pargyline did not increased the levels of NE and DA, but increased the level of 5-HT in rats pretreated by reserpine. Reserpine did not decreased the levels of NE, DA, and 5-HT in rats pretreated by pargyline. No potential effect was observed between reserpine and pargyline.