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Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity |
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| Authors: | Russo Emilio Citraro Rita Scicchitano Francesca Urzino Agostina Marra Rosario Rispoli Vincenzo De Sarro Giovambattista |
| Institution: | a Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Italy b National Council of Research, Institute of Neurological Science, Catanzaro, Italy c Department of Pharmacobiological Sciences, School of Pharmacy, University of Catanzaro, Italy |
| Abstract: | To evaluate the effects of Vigabatrin (VGB) treatment, on both absence seizure and depressive-like behaviour development in the WAG/Rij rat model of absence seizures. Early long-term treatment with VGB could alter the development of absence pathology, by significantly reducing seizure generation and synchronization in contrast to its pro-absence effects observed after acute or subchronic administration. We have demonstrated the antidepressant effects of a sub-chronic treatment with VGB in both wistar and WAG/Rij rats. In contrast, following an early long-term treatment, VGB antidepressant effects were only observable in WAG/Rij rats. In conclusion, VGB has antiepileptogenic and antidepressant properties in the WAG/Rij rat model despite its pro-absence effects suggesting that epilepsy and depression, in this animal model, are directly related and that seizure development inhibition also reduces the development of depressive behaviour. |
| Keywords: | Anticonvulsant Absence Epileptogenesis SWD Forced swimming test |
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