Effects of D-cycloserine and midazolam on the expression of the GABA-A alpha-2 receptor subunits in brain structures of fear conditioned rats |
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| Authors: | Wisłowska-Stanek Aleksandra Lehner Małgorzata Skórzewska Anna Maciejak Piotr Szyndler Janusz Turzyńska Danuta Sobolewska Alicja Płaźnik Adam |
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| Affiliation: | a Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26/28 Krakowskie Przedmie?cie Street, 00-927 Warsaw, Poland
b Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957 Warsaw, Poland |
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| Abstract: | The role of the GABA-A alpha-2 receptor subunit in the basolateral amygdala (BLA), dentate gyrus of the hippocampus (DG) and prefrontal cortex (M2 area) during a fear session (performed one week after the conditioned fear test), was studied. We employed a model of high (HR) and low anxiety (LR) rats divided according to their conditioned freezing response. Pretreatment of rats with d-cycloserine immediately before the fear session attenuated fear response in HR and LR rats and increased the density of alpha-2 subunits in the BLA, M2 area and DG of HR animals. The less potent behavioural influence of midazolam (in HR group only) was linked to the increased expression of alpha-2 subunit in M2 area and DG. These results support a role of the GABA-A receptor alpha-2 subunit in processing of emotional cortico-hippocampal input to the BLA. |
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| Keywords: | smallcaps" >d-cycloserine Midazolam GABA-A alpha-2 receptor subunit Limbic structures Fear conditioned rats |
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