骨源性碱性磷酸酶与小儿佝偻病的早期诊断

目的：探讨骨源性碱性磷酸酶（BAP）测定对小儿佝偻病的早期诊断价值。方法：对2008年10月～2009年4月儿童保健门诊体检的487例3个月～2岁小儿进行末梢血小儿骨源性碱性磷酸酶（NBAP）活性检测，并按卫生部颁发的婴幼儿佝偻病预防方案对487例小儿进行佝偻病临床筛查。结果：487例3个月～2岁小儿中NBAP阳性率为34．91％，而临床筛查佝偻病患儿为65例，阳性率为13．35％。结论：NBAP检测方法简单，灵敏度高，对小儿佝偻病早期诊断、预防具有较好的临床意义。

Bone alkaline phosphatase and the early diagnosis of rickets in children

Objective： To explore the early diagnosis value of determination bone alkaline phosphatase （NBAP） in children with rickets. Methods： 487 health examinated children in child health care clinic, aged 3 months to 2 years, were detected the activity of peripheral blood NBAP. And clinical screening was carried out on 487 children with richets, according to the infant tickets prevention project issued by Ministry of Public Health. Results： In the 487 children aged 3 months to 2 years, the NBAP positive rate was 34.91%, while 65 rachitic children were diagnosed through clinical screening, the positive rate was 13.35%. Conclusion： NBAP detection method is simple, high sensitivity, and of great significance in early diagnosis and prevention of infant rickets.