| 舒他西林甲磺酸盐体内抗菌作用研究 |
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| 引用本文： | 陈琼,许军,李家泰,北京医科大学临床药理研究所.舒他西林甲磺酸盐体内抗菌作用研究[J].中国抗生素杂志,1997(2). |
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| 作者姓名： | 陈琼 许军 李家泰 北京医科大学临床药理研究所 |
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| 作者单位： | 北京医科大学附属第一医院 |
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| 摘 要： | 舒他西林对４种细菌（金葡球菌、肺炎链球菌、大肠杆菌和肺炎克雷伯氏杆菌）共８个菌株分别感染小鼠的体内抗菌作用进行了研究，并以氨苄西林作为对照，以评价舒他西林对小鼠败血症的实验治疗疗效。实验结果显示：对金葡球菌、大肠杆菌和肺炎克雷伯氏杆菌，舒他西林的ＥＤ５０分别是氨苄西林ＥＤ５０的１／２～１／３、１／５～１／６和１／２～１／３，舒他西林的体内抗菌作用优于氨苄西林（Ｐ＜０．０１）。对氨苄西林敏感的肺炎链球菌，两药均显示出强大的抗菌活性，舒他西林的ＥＤ５０为氨苄西林的２～３倍，其抗菌活性逊于氨苄西林（Ｐ＜０．０１）。
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| 关 键 词： | 舒他西林 氨苄西林 体内抗菌作用 小鼠败血症模型 |
In vivo activity of sultamicillin tosilate |
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| Chen Qiong,Xu Jun and Li Jiatai.In vivo activity of sultamicillin tosilate[J].Chinese Journal of Antibiotics,1997(2). |
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| Authors: | Chen Qiong Xu Jun and Li Jiatai |
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| Abstract: | The in vivo activity of sultamicillin tosilate was compared with that of ampicilin against mice infections caused by 8 clinical isolates. The value of ED 50 of sulta micillin tosilate were 89.34, 62.5 mg/kg against S.aureus ; 212.3, 238.7 mg/kg against K.pneumoniae , 186.9, 185.2mg/kg against E.coli respectively, which were lower than those of ampicillin. The value of ED 50 of sultamicillin tosilate were 1.50, 1.87mg/kg against Strep.pneumoniae , which were higher than those of ampicillin. Our results showed that the in vivo activity of sultamicillin tosilate were stronger than those of ampicillin in infected mice by S.aureus, K.pneumoniae and E.coli . |
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| Keywords: | In vivo activity Sultamicillin tosilate Ampicillin |
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