急性脑卒中患者超敏C反应蛋白动态变化

目的：探讨超敏C反应蛋白动态变化与急性脑卒中患者临床转归的关系。方法：急性脑卒中患者157例按预后分为存活组（128例）与死亡组（29例），按病因分为脑梗死组113例和脑出血组44例。比较各组患者发病第1、7、14、21天的血压、神经功能评分、实验室检查及超敏C反应蛋白变化。结果：脑卒中患者发病第1天超敏C反应蛋白明显增加，存活组患者随着病情好转，血压下降、神经功能评分改善，超敏C反应蛋白逐渐下降；死亡组患者超敏C反应蛋白随神经功能评分恶化呈上升趋势，2组比较差异有统计学意义（P〈0．05）。脑梗死组和脑出血组患者血压、神经功能评分、常规生化检查及超敏C反应蛋白变化差异无统计学意义（P〉0．05）。结论：动态观察超敏C反应蛋白变化，有助于判断急性脑卒中患者的临床转归和预后。

Dynamic changes of high sensitivity C-reactive protein in patients with acute stroke

Objective To investigate the relationship between dynamic changes of high sensitivity C-reactive protein and the clinical prognosis of acute stroke. Methods One hundred and fifty-seven patients with acute stroke were divided into survival group（n = 128） and death group（n= 29） according to the prognosis, or infarction group （n=113） and hemorrhage group（n=44） according to the cause of disease. The blood pressure, the Chinese Stroke Scale, blood biochemical tests and the level of high sensitivity C-reactive protein were measured in 1,7,14, and 21 days after the onset of stroke and compared between group. Results After acute stroke, the level of high sensitivity C- reactive protein in all patients increased significantly at the first day of the onset. In the survival group, with the disease improvement, the blood pressure was controlled, neurological function recovered and high sensitivity C reactive protein decreased gradually. In death group, the level of high sensitivity C-reactive protein showed a rising trend with the deterioration of neurological function, which showed a statistic difference compared with the survival group（P〈0.05）. There were no statistic differences in the changes of blood pressure, Chinese Stroke Scale, blood biochemical tests and high sensitivity C reactive protein between infarction group and hemorrhage group（P〉0.05）. Conclusion The dynamic changes of high sensitivity C-reactive protein can be used to predict the clinical outcome and prognosis of acute stroke.