| 淫羊藿甙对血管平滑肌的作用 |
| |
| 引用本文： | 王敏,刘崇铭,张宝凤. 淫羊藿甙对血管平滑肌的作用[J]. 沈阳药科大学学报, 1993, 0(3) |
| |
| 作者姓名： | 王敏 刘崇铭 张宝凤 |
| |
| 作者单位： | 沈阳药学院生理学教研室(王敏，刘崇铭)，沈阳药学院生理学教研室(张宝凤) |
| |
| 摘 要： | 用离体家兔和狗动脉环,探讨EI扩张血管的机理。EI对TA,MA,CA和CBA的静息张力均有一定的降低作用;EI不同于Phen,而与Ver,Pap相似,以非竞争性拮抗NE收缩TA环的作用;EI能明显减弱NE收缩TA环作用中Ca~(++)内流依赖性部分,而对NE所致快速收缩反应无明显影响;EI能够降低高K~+所致TA,MA和CA,5-HT所致CBA的收缩反应。上述结果提示:EI具有抑制血管平滑肌细胞外Ca~(++)内流作用,这可能是EI扩张血管的主要机理。
|
| 关 键 词： | 淫羊藿甙 动脉环 量-效曲线 |
EFFECTS OF EPIMEDIUM ICARIINE ON RABBIT AND DOG VASCULAR SMOOTH MUSCLE |
| |
| Wang Min Liu Chonming Zhang Baofeng Dept. of Phys.. EFFECTS OF EPIMEDIUM ICARIINE ON RABBIT AND DOG VASCULAR SMOOTH MUSCLE[J]. Journal of Shenyang Pharmaceutical University, 1993, 0(3) |
| |
| Authors: | Wang Min Liu Chonming Zhang Baofeng Dept. of Phys. |
| |
| Affiliation: | Wang Min Liu Chonming Zhang Baofeng Dept. of Phys. |
| |
| Abstract: | EI can decrease the resting tension of blood vessel ring. The effect of EI,Ver, Pap, & Phen on NE dose-response curves was studied in rabbit TA. While Phen competitively antagonized NE, EI, & Ver,Pap also antagonized NE, but in a non-competitive manner. In Ca~(2+)-free Kreb-Henseleit solution. NE caused initial fast response which could not be caused by EI, while with Ca~(2+)added, Ca~(2+)-dependant response was markedly reduced by EI. Moreover, EI inhibited contraction evoked by K~+in rings of TA,MA and CA and inhibited the contraction of CBA ring induced by 5-HT,too. These findings suggest that El-induced vasodilation results from its inhibiting against receptoroperated and potential-dependant calcium influx. |
| |
| Keywords: | Epimedium Icariine Blood vessel ring Dose-response curves |
| 本文献已被 CNKI 等数据库收录！ |
|
