Excess fatigue as a precursor of myocardial infarction

To test the hypothesis that feelings of exhausion are predictiveof future coronary heart disease, a prospective study was doneamong 3877 males, aged 39–65. Feelings of exhaustion wereassessed by the Maastricht Questionnaire. Among those who werefree of coronary heart disease at screening, 59 subjects experienceda fatal or non-fatal myocardial infarction during the 4.2 yearfollow-up period. A multiple logistic regression analysis revealedthat feeling of exhausion were predictive of future myocardialinfarction when controlling simultaneously for blood pressure,smoking, cholesterol, age and the use of antihypertensive drugs.