| Effect of Electroacupuncture on Reperfusion Ventricular Arrhythmia in Rat |
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| 作者姓名： | 曾青 李熳 欧阳兴飚 农艺 刘晓春 施静 关新民 |
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| 作者单位： | Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030，Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030，Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030，Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030，Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030，Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030，Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 |
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| 基金项目： | ProjectsupportedbythegrantofMajorResearchPlanofNationalNatureScienceFoundationofP.R.China(90209009). |
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| 摘 要： | Clinically,heartthrombolytictreatmentandopen heartsurgerypossiblygiverisetosevereven triculararrhythmia,evenlethalarrhythmia.Therefore,thesearchforpreventingtheheartfromreperfusion inducedmalignantarrhythmiashasbeenatopicofimmenseinterest.Thereisalargebodyofevidencesupportingthatelectroacu puncture(EA)at"Neiguan"acupointhasastrongprotectiveeffectonischemicmyocardium1].OurpreviousstudyfoundthatEAatthe"Neiguan"and"Lingdao"acupointsincreasedthethresholdofventricularfibrillationinratswithacute…
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| 关 键 词： | acute myocardial ischemia ventricular arrhythmia electroacupuncture β-adrenoceptors M-cholinergic receptor |
| 收稿时间： | 2005-12-28 |
Effect of electroacupuncture on reperfusion ventricular arrhythmia in rat |
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| Zeng Qing,Li Man,Ouyang Xingbiao,Nong Yi,Liu Xiaochun,Shi Jing,Guan Xinmin.Effect of Electroacupuncture on Reperfusion Ventricular Arrhythmia in Rat[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(3):269-271. |
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| Authors: | Zeng Qing Li Man Ouyang Xingbiao Nong Yi Liu Xiaochun Shi Jing Guan Xinmin |
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| Institution: | Department of Neurobiology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030 |
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| Abstract: | Summary Protective effect and mechanism of electroacupuncture (EA) on acute reperfusion ventricular arrhthmia was investigated. Ventricular
arrhythmia was induced by occlusion of the proximal left anterior descend (LAD) branch of coronary artery for 5 min and followed
with 15 min reperfusion. EA on acupoint “Neiguan”, “Jianshi” was performed at 30 min before ligation and continued another
5 min during ischemia. Isoprenaline (20, 30 and 50 μg/kg) or atropine (1 mg/kg) was intravenously injected at 5min before
ischemia. The results showed that EA significantly decreased the incidence of ischemia/reperfusion (I/R) induced ventricular
tachycardia (VT), ventricular fibrillation (VF) and mortality as compared to I/R group. Atropine partially suppressed the
EAs effect of antiarrhythmia; Isoprenaline increased the incidence and severity of reperfusion arrhythmia, which was inhibited
by EA, but this inhibition of EA was blocked with increasing dose of isoprenaline. The results indicated that EA treatment
could prevent the occurrence of reperfusion ventricular arrhythmia in rats with myocardial ischemia, and its mechanism might
be related to the regulation of EA on the β-adrenoceptors and M-cholinergic receptor activation in myocardium.
Zeng Qing, female, born in 1961, Associate Professor
Project supported by the grant of Major Research Plan of National Nature Science Foundation of P. R. China (90209009). |
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| Keywords: | acute myocardial ischemia ventricular arrhythmia electroacupuncture M-cholinergic receptor |
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