| 人胎儿卵巢免疫原性的研究 |
| |
| 引用本文： | 刘晓红,郑英. 人胎儿卵巢免疫原性的研究[J]. 内蒙古医学杂志, 2003, 35(6): 471-474 |
| |
| 作者姓名： | 刘晓红 郑英 |
| |
| 作者单位： | 1. 北京市海淀区妇幼保健院产前筛查中心,北京,100080
2. 河南医科大学第二附属医院妇产科,河南,郑州,450003 |
| |
| 摘 要： | 目的 :比较成人卵巢、胎儿卵巢免疫原性的差异 ,以及培养前后胎儿卵巢免疫原性的变化。方法 :对成人及培养前后胎儿卵巢的冰冻切片用HLA -ABC及HLA -DR单克隆抗体进行免疫组织化学染色 ,观察其阳性细胞形态及分布并计数。结果 :成人卵巢内HLA -ABC及HLA -DR抗原含量显著多于胎儿卵巢 (P <0 0 0 1) ,且培养后胎儿卵巢HLA -DR抗原含量显著低于培养前 (P <0 0 1) ,随培养天数的增加HLA -DR抗原含量逐渐减少 (P <0 0 1)。结论 :胎儿卵巢的免疫原性低于成人卵巢 ,且培养后进一步降低。以培养一段时间的胎儿卵巢作为移植供体 ,必将提高临床卵巢移植的成功率。
|
| 关 键 词： | 胎儿卵巢 免疫原性 人白细胞抗原 HLA 卵巢移植 免疫组织化学 组织培养 |
| 文章编号： | 1004-0951(2003)06-0471-04 |
| 修稿时间： | 2003-07-23 |
The Study of The Immunogenicity in The Human Fetal Ovary |
| |
| LIU Xiao-hong,ZHENG Ying. The Study of The Immunogenicity in The Human Fetal Ovary[J]. Inner Mongolia Medical Journal, 2003, 35(6): 471-474 |
| |
| Authors: | LIU Xiao-hong ZHENG Ying |
| |
| Abstract: | Objective:To compare the immunogenicity of adult ovary,uncultured and cultured fetal ovary.Methods:To observe the expression of HLA-ABC and HCA-DR antigens by using immunohistochemical method on the frozen sections of adult and fetal ovary.Results:The HLA-ABC and HLA-DR antigens in adult ovary were significantly higher than that in.The HLA-DR antigen in cultured fetal ovary were significantly higher than that in unculturedone,and they decreased following with the increase of cultured days.Conclusions:The immunogenicity of fetal ovary is lower than that of adult ovary,and reduce after being cultured.As a graft of ovary transplantation,the cultured fetal ovary may prolong the survival rate of grafts. |
| |
| Keywords: | Fetal ovary Immunogenicity Human leukocyte antigen Transplantation Immunohistochemistry Tissue culture |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
