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| 载脂蛋白B基因多态性与心肌梗死的关系 | |
| 引用本文： | 臧彬,李海宁,郭津津,吴可光.载脂蛋白B基因多态性与心肌梗死的关系[J].中国实用内科杂志,2001,21(12):723-724. |
| 作者姓名： | 臧彬 李海宁 郭津津 吴可光 |
| 作者单位： | 1. 中国医科大学第二临床学院心内科沈阳,110004 2. 沈阳市胸科医院内科,110013 3. 中国医科大学第二临床学院心内科，沈阳,110004 |
| 摘 要： | 目的研究载脂蛋白B(apoB)基因多态性与心肌梗死发病的关系.方法用聚合酶链反应(PCR)法对65例心肌梗死(MI)患者和60例正常人apoB基因XbaI和MspI两个酶切位点上限制性片段长度多态性(RFLPs)进行检测.结果MI组Xbal酶切位点上X+等位基因频率显著高于对照组,分别为0.092和0.025(P<0.05).MspI酶切点位上M-等位基因相对频率在MI组和对照组之间无明显差异.结论XbaIRFLPs可以作为MI的独立预测指标. |
| 关 键 词： | 载脂蛋白B 基因 多态性 心肌梗死 |
| 文章编号： | 1005-2194(2001)12-0723-02 |
| 修稿时间： | 2001年6月10日 |
The relation between polymorphisms of apliporprotein B gene and myocardial infarction. |
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| Zangbin,Li Haining,Guo jinjin,Wu Keguang.The relation between polymorphisms of apliporprotein B gene and myocardial infarction.[J].Chinese Journal of Practical Internal Medicine,2001,21(12):723-724. | |
| Authors: | Zangbin Li Haining Guo jinjin Wu Keguang |
| Institution: | Zangbin,Li Haining,Guo jinjin,Wu Keguang,Department of Cardiology,No.2 Clinical Hospital of China Medical University,110004 |
| Abstract: | Objective To study the relationship between the apolipoprotein B(apo B) gene polymorphism and mycoardial infarction.Methods Two polymorphic sites of the apo B gene,Xba1 and Msp1 were examined by PCR in a sample of 65 patients with myocardial infarction(MI) and 60 healthy individuals selected from a population of the chinese Han nationality.Results The frequency of X allele(presence of Xba1 cutting site)in MI cases was significantly higher than that in controls(P<0 05),respectively 0 092 and 0 025.The frequency of M-allele(presence of Msp1 cutting site) was no difference between MI cases and controls in statistics.Conclusions Genetic variation at Xba1 site of apo B may be independent prediction in the myocardial infarction. |
| Keywords: | Aplipoprotien B gene Polymorphism Myocardial infarction |
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