凋亡抑制蛋白FLIP在脑星形细胞瘤中的表达和意义

目的 :检测脑星形细胞瘤中凋亡抑制蛋白FLIP的表达 ,并进而揭示其在肿瘤发生发展中的意义 .方法 :采用免疫组织化学技术和蛋白印迹技术 ,分析 4 8例星形细胞瘤 (其中Ⅰ级 1 4例 ,Ⅱ级 1 8例 ,Ⅲ级 1 0例 ,Ⅳ级 6例 )标本和 1 0例颅脑损伤标本中FLIP蛋白的表达 ,并对不同级别星形细胞瘤中该蛋白的表达进行统计学比较 .结果 :低级别星形细胞瘤与高级别星形细胞瘤中FLIP的表达水平有显著差异(P <0 .0 1 ) .结论 :FLIP的表达水平与星形细胞瘤恶性程度密切相关 ,这可能为阐明星形细胞瘤恶性进展的分子机制 ,并为探索其有效治疗办法提供新的思路

Expression and significance of inhibitor apoptosis protein of FLIP in human astrocytomas

AIM: To detect the expression of inhibitor apoptosis protein of FLIP (FLICE inhibitory protein) in human astrocytomas and to explore its significance for the genesis and development of astrocytomas. METHODS: The expression of FLIP in 48 cases of astrocytomas and brain injury specimens was detected by immunohistochemical and Western-blot techniques. The different expression levels of FLIP in astrocytomas of different degree were compared by statistical methods. RESULTS: There were significant differences in the expression level of FLIP between the low grade astrocytoma and the high grade astrocytoma. CONCLUSION: The expression level of FLIP is closely related to the malignant degree of astrocytomas, which may help to explore the molecular mechanism of astrocytoma development and find an effective therapeutic method for this kind of tumor.