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Gastrin Receptor Gene Expression in Several Human Carcinomas |
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| Authors: | Yumi Matsushima Yoshikazu Kinoshita Hirohisa Nakata Yoko Inomoto-Naribayashi Masakyo Asahara Chiharu Kawanami Akira Nakamura Mitsuhiro Ito Toshimitsu Matsui Takato Fujiwara Hidenobu Watanabe Tsutomu Chiba |
| Affiliation: | Division of Gerontology, Department of Internal Medicine, Kobe University School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe 650;The Third Division, Department of Internal Medicine, Kobe University School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe 650;Department of Pathology, Niigata University School of Medicine, 757 Ichibancho, Asahimachi-dori, Niigata 951 |
| Abstract: | Gastrin has been shown to enhance the growth of various human tumors. The present study was designed to examine the gastrin receptor gene expression in various human carcinoma cell lines and in surgically resected carcinoma tissues. By Northern blot analysis, gastrin receptor mRNA was detected in 3 out of 7 small cell lung carcinoma cell lines. Gastrin receptor mRNA was also expressed in one out of 8 colon carcinoma cell lines and 2 out of 10 colon carcinoma tissues. Moreover, one of two small cell carcinoma cell lines of the stomach clearly expressed gastrin receptor mRNA. However, none of the gastric adenocarcinoma cell lines or surgically resected gastric adenocarcinomas tested had any detectable expression of gastrin receptor gene. These findings may suggest a role of gastrin receptor in the growth and differentiation of certain human carcinomas. |
| Keywords: | Gastrin receptor Small cell lung cancer Small cell gastric cancer Gastric cancer Colon cancer |