| 鸭儿芹总黄酮对四氯化碳致急性肝损伤小鼠的保护作用 |
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| 引用本文： | 田琳,龚其海. 鸭儿芹总黄酮对四氯化碳致急性肝损伤小鼠的保护作用[J]. 遵义医学院学报, 2008, 31(1): 8-10 |
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| 作者姓名： | 田琳 龚其海 |
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| 作者单位： | 1. 遵义医学院,机能学教研室,贵州,遵义,563000
2. 遵义医学院药理学教研室,贵州,遵义,563000 |
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| 摘 要： | 目的观察鸭儿芹总黄酮对四氯化碳致急性肝损伤小鼠的保护作用。方法选用昆明种小鼠，鸭儿芹总黄酮（40、80、160mg／kg）三种剂量连续灌胃给药5d后，腹腔注射0．1％CCl4（10ml/kg）致小鼠急性肝损伤，测定不同剂量的鸭儿芹总黄酮对小鼠血清中丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）活性，肝匀浆中超氧化物歧化酶（SOD）活性及丙二醛（MDA）含量。结果3种剂量的鸭儿芹总黄酮均能显著地降低小鼠血清ALT和AST活性，升高小鼠肝脏SOD活性，降低肝脏MDA含量。结论鸭儿芹总黄酮对由四氯化碳所致的急性肝脏损伤有保护作用，其机制与提高小鼠的抗氧化能力有关。
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| 关 键 词： | 鸭儿芹总黄酮 肝损伤 丙氨酸转氨酶 天冬氨酸转氨酶 超氧化物歧化酶 丙二醛 |
| 文章编号： | 1000-2715(2008)01-0008-03 |
| 修稿时间： | 2008-01-15 |
Protective effect of total flavonoids from Cryptotaenia japonica Hassk on CCl4-induced acute liver injury in mice |
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| TIAN Lin,GONG Qi-Hai. Protective effect of total flavonoids from Cryptotaenia japonica Hassk on CCl4-induced acute liver injury in mice[J]. Acta Academiae Medicine Zunyi, 2008, 31(1): 8-10 |
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| Authors: | TIAN Lin GONG Qi-Hai |
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| Affiliation: | TIAN Lin1,GONG Qi-Hai2 ( 1.Department of Medical Functional Experiment,Zunyi Medical College,Guizhou Zunyi 563003,China,2. Department of Pharmacology,Guizhou Zunyi,563000,China) |
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| Abstract: | Objective To investigate the protective effect of total flavonoids from Cryptotaenia japonica Hassk on CCl4-induced acute liver injury in mice. Methods Kunming mice were used in the experiment . The mice were administrated by gavage with total flavonoids from Cryptotaenia japonica Hassk at the dose of(40, 80,160 mg/kg)respectively. The liver injury model was established by injection of CCl4 to abdominal cavity. Alanine transaminase (ALT) and aspartate transaminase (AST) in serum,activities of superoxidase(S... |
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| Keywords: | Total flavonoids Cryptotaenia japonica Hassk liver injury ALT AST SOD MDA |
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