In vivo MRI monitoring nerve regeneration of acute peripheral nerve traction injury following mesenchymal stem cell transplantation |
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Authors: | Duan Xiao-Hui Cheng Li-Na Zhang Fang Liu Jun Guo Ruo-Mi Zhong Xiao-Mei Wen Xue-Hua Shen Jun |
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Affiliation: | Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, Guangdong, China. |
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Abstract: | ObjectiveTo assess the continuous process of nerve regeneration in acute peripheral nerve traction injury treated with mesenchymal stem cells (MSCs) transplantation using MRI.Materials and methods1 week after acute nerve traction injury was established in the sciatic nerve of 48 New Zealand white rabbits, 5 × 105 MSCs and vehicle alone were grafted to the acutely distracted sciatic nerves each in 24 animals. Serial MRI and T1 and T2 measurements of the injured nerves were performed with a 1.5-T scanner and functional recovery was recorded over a 10-week follow-up period, with histological assessments performed at regular intervals.ResultsCompared with vehicle control, nerves grafted with MSCs had better functional recovery and showed improved nerve regeneration, with a sustained increase of T1 and T2 values during the phase of regeneration.ConclusionMRI could be used to monitor the enhanced nerve regeneration in acute peripheral nerve traction injury treated with MSC transplantation, reflected by a prolonged increase in T1 and T2 values of the injured nerves. |
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Keywords: | Magnetic resonance imaging Peripheral nerves injury Mesenchymal stem cells Stem cell transplantation |
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