喹硫平与利培酮对血清催乳素水平的影响

目的探讨喹硫平与利培酮对女性精神分裂症患者血清催乳素（PRL）水平的影响及血清PRL水平与药物疗效的相互关系。方法对80例女性精神分裂症患者随机分为两组，分别以喹硫平或利培酮治疗。于治疗前及治疗8周时各测一次血清PRL浓度。以阳性与阴性症状量表（PANSS）评定疗效。结果经8周治疗，两组PANSS基线评分和治疗后减分值差异无统计学意义，但利培酮组血清PRL水平显著高于喹硫平组。血清PRL浓度与临床疗效无显著相关。结论喹硫平对女性精神分裂症患者血清PRL水平基本无影响，更适于女性精神分裂症使用。

The effects of seroquel and rLsperidone on serum prolactin levels of female schizophrenia

Objective To explore the effects on serum prolactin（PRL） of seroquel and rrisperidong in the treatmemt of female schizophrenic patients and the relationship between the level of serum PRL and drug＇s effect. Methods 80 female schizophrenic patients were treated with seroquel or risperidone randomly. The levels of serum PRL were measured and the scores of PANSS were evaluated before treatment and at the 8th week respectively. Results There were no significant differences in PANSS basal scores and the decreased score value after the treatment in two groups. The level of serum PRL in risperidone group increased markedly than seroquel group. Both drug＇ s effect are not related with serum PRL. Conclusion Seroquel has less effect on the level of serum PRL in female schizophrenic patients. So seroquel is more suitable for the treatment of female schizo-phrenic patients.