低分子量肝素对增殖性肾炎的疗效观察

目的为观察低分子量肝素对增殖性肾炎的疗效观察。方法对62例经肾活检证实组织学改变都有明显的系膜细胞增殖，并有不同程度硬化和肾小球内凝血的患者，随机分为两组，对照组用激素、环磷酰胺、洛丁新治疗；观察组在上述治疗基础上用低分子量肝素治疗。结果治疗组患者治疗4周后尿蛋白明显减少，血清白蛋白明显增高，总胆固醇下降，与对照组比较差异有显著性（P〈0．05）。结论本研究提示低分子量肝素可使增殖性肾炎患者尿蛋白减少，有利于肾病综合征的缓解，且出血危险性小，便于长期使用。

Effecfs of low-molecular-weight peparin on proliferative glomervlonephrieis

Objective To investigate the effects of LMWH on proliferative nephritis. Methods Ran-domized 62 patients who had obvious mesangial cell proliferation testified by renal biopsy into 2 groups according to age, course, clinical manifestations and the pathological lesions. The patients in the control group were given steroid,cyclophosphamide and bennazipril, and the patients in the treated group LMWH besides the medicine used in the control group. Results Observed a significant decrease in proteinuria and in crease in serum albumin in the treated group compared with those in the control group after 4 weeks of treatment （P〈0.05）. Conclusion The date indicated that LMWH can decrease the proteinuria in the patients who have intraglomerular coagulation and proliferative nephritis with various degrees of sclerosis,and it is helpful to relieve nephrotie syndrome,because the less risk of hemorrhage,LMWH can be used for Long-term treatment.