Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram |
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| Authors: | Email author" target="_blank">Paul?D?CareyEmail author James?Warwick Dana?JH?Niehaus Geoffrey?van der Linden Barend?B?van Heerden Brian?H?Harvey Soraya?Seedat Dan?J?Stein |
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| Institution: | (1) MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, 7505 Tygerberg, Cape Town, South Africa;(2) Department of Nuclear Medicine, University of Stellenbosch, 7505 Tygerberg, Cape Town, South Africa;(3) School of Pharmacy (Pharmacology), North-West University, Potchefstroom, South Africa |
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| Abstract: | Background Several studies have now examined the effects of selective serotonin reuptake inhibitor (SSRI) treatment on brain function
in a variety of anxiety disorders including obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), and
social anxiety disorder (social phobia) (SAD). Regional changes in cerebral perfusion following SSRI treatment have been shown
for all three disorders. The orbitofrontal cortex (OFC) (OCD), caudate (OCD), medial pre-frontal/cingulate (OCD, SAD, PTSD),
temporal (OCD, SAD, PTSD) and, thalamic regions (OCD, SAD) are some of those implicated. Some data also suggests that higher
perfusion pre-treatment in the anterior cingulate (PTSD), OFC, caudate (OCD) and antero-lateral temporal region (SAD) predicts
subsequent treatment response. This paper further examines the notion of overlap in the neurocircuitry of treatment and indeed
treatment response across anxiety disorders with SSRI treatment. |
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