冠心病患者血浆血栓调节蛋白水平的测定及其临床意义

目的　测定冠心病患者血浆血栓调节蛋白 ( throm bom odulin,TM)水平并探讨其临床意义。方法　急性心肌梗死、不稳定型心绞痛、稳定型心绞痛三组患者及正常对照组 ,抽取血浆并用酶联免疫吸附试验测量其血浆 TM水平。结果　急性心肌梗死组、不稳定型心绞痛组、稳定型心绞痛组血浆 TM水平均高于正常对照组 ( P<0 .0 5 ) ;急性心肌梗死组与不稳定型心绞痛组间患者血浆 TM水平没有显著性差异 ( P>0 .0 5 ) ,但均高于稳定型心绞痛组和正常对照组 ( P<0 .0 5 )。结论　血浆可溶性 TM水平是反映冠心病患者内皮细胞损伤程度和范围的良好标志 ,对急性心肌梗死、不稳定型心绞痛、稳定型心绞痛的鉴别有一定的临床指导意义

Plasma levels of thrombomodulin in patients with coronary heart disease and their clinical significance

Objective To investigate the levels of plasma thrombomodulin(TM) and the clinical significance of TM in patients with coronary heart disease. Methods The levels of plasma thrombomodulin were measured by enzyme linked immunosorbent assay in patients who were divided into three groups: acute myocardial infarction, unstable angina pectoris and stable angina pectoris. Results The TM levels in three groups were all higher than the normal group. Conclusion Levels of plasma TM are valuable in evaluation of damage degrees of endothelial cell in patients with coronary heart disease, and they were different in the acute myocardial infarction, unstable angina pectoris and stable angina pectoris.