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Cerebral blood flow and oxygenation during head-up tilt in patients with multiple system atrophy and healthy control subjects |
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| Authors: | Asahina Masato Sato Jiro Tachibana Masatoshi Hattori Takamichi |
| Affiliation: | aDepartment of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260 8670, Japan bDepartment of Anesthesia, National Chiba Medical Center, 4-1-2 Tsubaki-mori, Chuo-ku, Chiba-shi, Chiba 260 8606, Japan cDepartment of Otolaryngology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260 8670, Japan |
| Abstract: | To assess cerebral hemodynamics in patients with multiple system atrophy (MSA), cerebral blood flow and oxygenation were evaluated in 7 MSA patients and 9 healthy controls during a head-up tilt test (HUT) by means of transcranial Doppler ultrasonography and near-infrared spectrophotometry. In the MSA patients examined, the perfusion pressure reduction during HUT was marked, but severe reduction in blood flow velocity was prevented because of a decrease in cerebrovascular resistance. The MSA patients showed no severe reduction in cerebral oxygenation during HUT. These findings indicate that our MSA patients exhibited a compensatory cerebral vasodilatation response to orthostatic hypotension. |
| Keywords: | Autonomic failure Cerebral autoregulation Cerebral blood flow Cerebral oxygenation Multiple system atrophy Orthostatic hypotension |
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