The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis |
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Authors: | Weiguang Yuan Lidan Xu Yuanxi Feng Yue Yang Wangyang Chen Jingwei Wang Da Pang and Dianjun Li |
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Institution: | (1) Institute of Cancer Prevention and Treatment, Harbin Medical University, Baojian Road 6, Nangang District, 150081 Harbin, China;(2) Department of Immunology, Harbin Medical University, 150081 Harbin, China;(3) Laboratory of Medical Genetics, Harbin Medical University, 150081 Harbin, China;(4) Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, 150081 Harbin, China;(5) Department of Surgery, The Third Affiliated Hospital of Harbin Medical University, 150081 Harbin, China; |
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Abstract: | It was reported that the functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase gene was associated with
breast cancer risk; however, the published studies have inconsistent conclusions. To elucidate the effect of hOGG1 Ser326Cys
on the susceptibility to breast cancer, all available studies were collected in this meta-analysis. We extracted the data
from 10 case–control studies that were published in the PubMed database from 2003 to 2008 using the search phrases “human
8-oxoguanine DNA glycosylase, hOGG1, OGG1, OGG, polymorphism, genetic variation, and breast cancer.” This meta-analysis included
4,963 breast cancer cases and 4,776 control subjects. The results showed that individuals who carrying the hOGG1 326Cys allele
in the additive model did not have significantly increased risk of breast cancer compared with those carrying the 326Ser allele
(P = 0.47, OR = 1.02; 95% CI = 0.96–1.09); similarly, no significant association between the hOGG1 326Cys allele and breast
cancer risk was found either in the recessive genetic model (P = 0.34, OR = 1.06; 95% CI = 0.94–1.18) for Cys/Cys versus Ser/Cys + Ser/Ser, or dominant genetic model (P = 0.78, OR = 1.01; 95% CI = 0.93–1.11) for Cys/Cys + Ser/Cys versus Ser/Ser. In the stratified analysis, the meta-analysis
showed the association between hOGG1 326Cys allele in the additive model and breast cancer was significant in European subjects
(P = 0.04, OR = 0.71; 95% CI = 0.51–0.98), and dominant genetic model (P = 0.004, OR = 0.44; 95% CI = 0.25–0.77). However, the association was not significant between this polymorphism and different
menopausal status (premenopausal and postmenopausal) and the other ethnicities (Asians and Americans). The meta-analysis suggested
that the hOGG1 326Cys allele plays a significant protective effect to breast cancer in European women. |
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