九里香叶中的化学成分

目的:研究九里香叶的药效物质基础。方法:利用制备薄层、反复硅胶色谱、半制备HPLC等方法进行分离纯化,根据理化性质及波谱数据对分离的化合物进行结构鉴定。结果:分离得到11个化合物,分别鉴定为5,7,3',4'-四甲氧基黄酮(1),5,7-二羟基-3',4',5'-三甲氧基黄酮(2),5-羟基-3,7,3',4'-四甲氧基黄酮(3),3-羟基-5,6,7,4'-四甲氧基黄酮(4),川陈皮素(5),香草酸(6),咖啡酸乙酯(7),5-羟基-7,3',4'-三甲氧基黄酮(8),3,5-二羟基-6,7,3',4'-四甲氧基黄酮(9),5,6,4-三羟基-3,7,-二甲氧基黄酮(10),山柰酚(11)。结论:3,4,6,9,10为首次从九里香叶中分离得到。

Chemical Constituents in Leaves of Murraya exotica

Objective: To study the effective substance basis of leaves of Murraya exotica. Method: Preparative TLC, repeated silica gel chromatograph, half-making HPLC were used to separate and purify the isolated compounds, which were structurally identified by the physical and chemical characters and the spectrum data. Result: Eleven compounds were obtained. They were 5, 7, 3', 4'-tetramethoxyflavone (1), 5, 7-dihydroxy-3', 4', 5'-trimethoxyflavone (2), 5-hydroxy-3, 7, 3', 4'-tetramethoxyflavone (3), 3-hydroxy-5, 6, 7, 4'-tetramethoxyflavone (4), nobiletin (5), vanillic acid (6), ethyl caffeate (7), 5-hydroxy-7, 3', 4'-trimethoxyflavone (8), 3, 5-dihydroxy-6, 7, 3', 4'-tetramethoxyflavone (9), 5, 6, 4-trihydroxy-3, 7-dimethoxyflavone (10), and kaemperol (11). Conclusion: The compounds 3, 4, 6, 9 and 10 were isolated from M.exotica for the first time.