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| 综合评分法优化复方丹参口腔速溶片制剂处方 | |
| 引用本文： | 胡容峰,朱家壁,彭代银,汤继辉,周安. 综合评分法优化复方丹参口腔速溶片制剂处方[J]. 中国中药杂志, 2006, 31(5): 380-382 |
| 作者姓名： | 胡容峰 朱家壁 彭代银 汤继辉 周安 |
| 作者单位： | 1. 中国药科大学,药剂研究所,江苏,南京,210009;安徽中医学院,药剂教研室,安徽,合肥,230038 2. 中国药科大学,药剂研究所,江苏,南京,210009 3. 安徽中医学院,药剂教研室,安徽,合肥,230038 |
| 基金项目： | 安徽省教育厅自然科学基金 |
| 摘 要： | 目的:优化复方丹参口腔速溶片处方,制备中药口服速释固体制剂。方法:以颗粒的流动性、片剂的崩解时间、片剂的硬度和片剂中有效成分的溶出速度为指标,采用正交设计综合评分法优化干法制粒制备复方丹参口腔速溶片的处方和制备工艺。结果:优化所得处方为微晶纤维素40%,羧甲基淀粉钠10%,糊精约15%。以此处方制备的复方丹参口腔速溶片在崩解时间不超过3 min,硬度为4.5 kg,有效成分的溶出速度参数T50为5 min。结论:优化所得处方合理稳定,复方丹参口腔速溶片具有明显的速释特征。 |
| 关 键 词： | 复方丹参口腔速溶片 正交设计 综合评分法 制备工艺 |
| 文章编号： | 1001-5302（2006）05-0380-03 |
| 收稿时间： | 2005-04-11 |
| 修稿时间： | 2005-04-11 |
Optimization of formulation of Fufang Danshen immediate release tablet by colligation score |
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| HU Rong-feng ;ZHU Jia-bi ;PENG Dai-yin ;TANG Ji-hui ;ZHOU An. Optimization of formulation of Fufang Danshen immediate release tablet by colligation score[J]. China Journal of Chinese Materia Medica, 2006, 31(5): 380-382 | |
| Authors: | HU Rong-feng ZHU Jia-bi PENG Dai-yin TANG Ji-hui ZHOU An |
| Affiliation: | 1. Institute of Pharmaceutics , China Pharmaceutical University , Nanjing 210009, China; 2. Department of Pharmaceutics , Arhui College of Traditional Chinese Medicine, Hefei 230038, China |
| Abstract: | Objective: To optimize the formulation of immediate release tablet.Method: The immediate release tablet was prepared by using dry granules.The preparation was optimized by using orthogonal design which took the flow property of granules,the hardness,the disintegrating time and the dissolution rate of the tablet as indices.Result: the optimized formulation contained 40% microcrystalline cellulose,10% sodium carboxymethyl starch and 15% dextrin.The hardness disintegrating time and T_(50)of the tablet were 4.5 kg,3 min,5 min respectively.Conclusion: It is successful to prepare on immediate release tablet using the optimized formula above. |
| Keywords: | Fufang Danshen immediate release tablet orthogonal design process colligationscore |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |