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Evaluation of Early Atherosclerosis in Patients with Inflammatory Bowel Disease
Authors:Hasan Kayahan  Ismail Sari  Nesat Cullu  Fahize Yuksel  Serdal Demir  Mesut Akarsu  Yigit Goktay  Belkis Unsal  Hale Akpinar
Institution:Department of Gastroenterology, School of Medicine, Dokuz Eylul University, Inciralti, 35340 Izmir, Turkey. kayahancup@gmail.com
Abstract:

Background

Data regarding early atherosclerosis and inflammatory bowel disease are limited and conflicting results are present.

Aims

The purpose of this study was to evaluate serological and sonographical evidence of subclinical vascular involvement in patients with inflammatory bowel disease.

Methods

Thirty-nine patients with inflammatory bowel disease (20 Crohn's disease, and 19 ulcerative colitis patients) and 31 healthy controls were consecutively enrolled in the study. Flow mediated dilatation of the brachial artery and intima media thickness assessments of the common carotid artery were measured sonographically. Soluble CD40 ligand levels were evaluated. Crohn's disease activity index and modified Truelove-Witt’s criteria were also noted.

Results

Age, sex distribution, serum lipids, smoking status, and intima media thickness of the common carotid artery were similar between the inflammatory bowel disease patients and controls (p > 0.05). However, both endothelium dependent and independent flow mediated dilatation values were significantly impaired in the inflammatory bowel disease group compared with healthy controls (p < 0.05). Erythrocyte sedimentation rate, C-reactive protein and soluble CD40 ligand values were significantly increased in inflammatory bowel disease patients compared with controls (p < 0.05), and soluble CD40 ligand was negatively correlated with flow mediated dilatation (r = ?0.3, p < 0.05). Flow mediated dilatation was significantly predicted from the concentrations of C-reactive protein and soluble CD40 ligand.

Conclusion

Functional atherosclerosis is present in inflammatory bowel disease before early structural changes occur in vasculature. Higher sCD40L may indicate worse vascular outcome for IBD.
Keywords:
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