| PPARα/γ双重激动剂与2型糖尿病 |
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| 引用本文： | YANG Jun,邹秀兰.PPARα/γ双重激动剂与2型糖尿病[J].医学综述,2008,14(16):2492-2496. |
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| 作者姓名： | YANG Jun 邹秀兰 |
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| 作者单位： | 宜昌市第一人民医院内分泌科,湖北宜昌,443000 |
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| 摘 要： | 越来越多的研究表明,肥胖和胰岛素抵抗能导致2型糖尿病的发病,对2型糖尿病的治疗方法也在不断改进。最近研究表明,过氧化物酶体增殖物激活受体α/γ(PPARα/γ)双重激动剂具有降血脂、改善胰岛素抵抗、抗炎、抗动脉粥样硬化等作用,是一类治疗糖尿病的新药,对其相关研究将有助于今后临床上更好的治疗2型糖尿病。
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| 关 键 词： | 2型糖尿病 胰岛素抵抗 肥胖 过氧化物酶体增殖物激活受体α/γ双重激动剂 |
Peroxisome Prollferator Activated Receptor α/γ Dual Agonists and Type 2 Diabetes Meilitus |
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| YANG Jun,ZOU Xiu-lan.Peroxisome Prollferator Activated Receptor α/γ Dual Agonists and Type 2 Diabetes Meilitus[J].Medical Recapitulate,2008,14(16):2492-2496. |
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| Authors: | YANG Jun ZOU Xiu-lan |
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| Institution: | YANG Jun1,ZOU Xiu-lan2.(1.Medical college of Three Gorges Universitiy,Yichang 443002,China,2.Department of Endocrinology,First People\'s Hospital of Yichang,Yichang 443000,China) |
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| Abstract: | Accumulated researches demostrated that obesity and insulin resistance（IR） can result in the genesis of type 2 diabetes mellitus（T2DM）. Therefore,there has much progress on the treatment of T2DM. Recent studies show that PPARα/γ dual agonists have many effects such as decreasing blood fat, improving insulin resistance, anti-inflammatory, anti-artherosclerosis （AS） and so on, and it is a new kind of drug, having distinct effects on T2 DM. So, the researches related to PPARα/γ dual agonists will do good to the therapy for T2DM in clinic. |
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| Keywords: | Type 2 diabetes mellitus Insulin resistance Obesity Peroxisome proliferator activated receptor α/γ dual agonists |
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