重组牛碱性成纤维细胞生长因子联合玻璃酸钠
对糖尿病性白内障超声乳化术后干眼症的影响分析 |
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引用本文: | 王文海,赵 莉,佀爱梅.重组牛碱性成纤维细胞生长因子联合玻璃酸钠
对糖尿病性白内障超声乳化术后干眼症的影响分析[J].大连医科大学学报,2016,38(3). |
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作者姓名: | 王文海 赵 莉 佀爱梅 |
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作者单位: | 陕西省荣誉军人康复医院 |
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摘 要: | 探讨重组牛碱性成纤维细胞生长因子联合玻璃酸钠治疗对糖尿病性白内障患者超声乳化术后干
眼症的影响。方法 选择2010年1月—2013年10月就诊的糖尿病性白内障行超声乳化术患者106例(145只
眼),随机数字表法分为对照组(A组50只眼)、玻璃酸钠治疗组(B组48只眼)和联合治疗组(C组47只眼)。
在术前、术后1d、术后1周、术后1个月进行主观干眼症状、泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)及角
膜荧光素染色(FL)检查。结果 术后1月,A组干眼主观症状、BUT和FL与术前相比差异仍有统计学意义(P
<005)。B组术后1周SIt、FL和术后1个月干眼主观症状、BUT接近术前水平(P>005)。C组术后l周干眼
主观症状、BUT、SIt和FL均接近术前水平(P>005)。结论 糖尿病性白内障患者行超声乳化手术后早期使用
重组牛碱性成纤维细胞生长因子联合玻璃酸钠治疗,更有利于改善症状、恢复泪膜稳定性。
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关 键 词: | 糖尿病 白内障超声乳化吸除术后 泪膜 玻璃酸钠 重组牛碱性成纤维细胞生长因子 |
Clinical study on the effect of combination therapy of sodium hyaluronate and recombinant bovine basic
fibroblast growth factor after phacoemulsification in diabetics |
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Abstract: | To study the efficacy of the corubined treatment with sodium hyaluronate ( HA) and recombinant
bovine basic fibroblast growth factor( r - bFGF) for II - diabetic patients after phacoemulsification. Methods A total of
106 11 - diabetic patients undergoing phacoemulsification were randomized divided into control group ( group A,50 eyes
with conventional therapy) , single treatment Group ( group B ,48 eyes with conventional therapy and HA) and combined
treatment group ( group C ,47 eyes with conventional therapy , HA and r - bFGF ) . Subjective symptoms , tear film break -
up time( BUT) .Schirmer I test ( SIt) and corneal fluorescein staining ( FL) were measured preoperatively and I day , I
week and I month postoperatively. Results In all groups. the BUT reduced greatly , SIt value and FL increased significantly
after phacoemulsification. Compared with preoperations in group A, subjective complains of dry eye increased and the
BUT reduced in I day, I week and I month postoperatively. So did FL. SIt value returned at postoperative value at I
month after operations( P < 0. 05 ). In group B , SIt value and FL returned to postoperative value at postoperative I week.
SO did subjective complains of clry eye and BUT at postoperative I month( P > 0. 05 ). There were no significant differ-
ences in subjective complains of dry eye,BUT. SIt and FL in group C in I week after phacoemulsification ( P > 0. 05 )
. Conclusion It can be more effective to relieve the dry eye symptoms for II diabetic patients to use combined treatment
with HA and r - bFGF at early stage after phacoemulsification. |
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Keywords: | Diabetes Phacoemulsification Tear film Hyaluronate r - bFCF |
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