甲硝唑联合头孢类抗生素对剖宫产切口感染患者血清白介素及其他炎性指标的影响

研究分析甲硝唑联合头孢类抗生素对剖宫产切口感染患者血清白介素及其他炎性指标的影响。方法　自２０１２年６月—２０１３年９月我院收治剖宫产切口感染患者中随机选取８６例作为研究对象，按入院的先后顺序分成对照组和观察组，每组各为４３例，对照组剖宫产切口感染患者仅用头孢类抗生素进行治疗，观察组患者在对照组患者治疗的基础之上联合使用甲硝唑进行治疗。比较两组患者的血清白介素和及其他炎性指标的差异。结果　治疗后５天时观察组患者血清白介素中的ＩＬ－２、ＩＬ－４、ＩＬ－６、ＩＬ－１０分别是（３３２±０２８）ｕｇ／ｌ、（４１２±０７８）ｕｇ／ｌ、（８１２±１２６）ｕｇ／ｌ、（５１２±０５６）ｕｇ／ｌ，其他炎性指标ｈｓ－ＣＲＰ、ＴＮＦ－ａ、ＩＮＦ－ｒ、ＮＯ分别（３２１±０３２）ｍｇ／ｌ、（９３３８±１０１２）ｕｇ／ｌ、（１４５６±１３２）ｕｇ／ｌ、（８１３６±１０６８）ｕｇ／ｌ，均低于对照组，且两组之间存在显著性差异（Ｐ＞００５）。结论　甲硝唑联合头孢类抗生素用于治疗剖宫产切口感染患者疗效显著，具有积极的临床应用价值。

The effect of metronidazole combined with cephalosporin antibiotics for cesarean section patients with serum interleukin and other inflammatory indicators incision infection

To study the effect of metronidazole corubined with cephalosporin antibiotics for cesarean section patients with serum interleukin and other inflammatory indicators incision infection. Methods from 2012 June t0 2013 September in our hospital were incision infection of cesarean section in 86 cases of patients were randomly selected as the research object, according to admission order divided into control group and observation group, each group included 43 cases, the control group patients with cesarean section only cephalosporins for treatment of wound infection, the patients in observation group on the basis of the control group patients were treated with metronidazole. Comparison of serum m- terleukin two groups of patients and other inflarumatory index. Results after 5 days when the serum interleukin in IL - 2 , 11 -4. 11 - 6 , IL - 10 were ( 3. 32 + 0. 28 ) uUI, (4. 12 + 0. 78) ug/l, ( 8. 12 + 1. 26) ug/l, (5. 12 0. 56) ug/l, other inflammatory markers hs - CRP. TNF - a. INF - r, NO respectively. (3. 21 + 0. 32) mg/l, ( 93. 38 + 10. 12) ug/l, ( 14. 56 + 1. 32) ug/l, ( 81. 36 + 10. 68) ug/l, were lower than the control group, and there was significant difference between the two groups ( P > 0. 05 ). Conclusion metronidazole and cephalosporin antibiotics are used to treat patients with cesarean section were wound infection . with positive clinical application value.