慢性丙型肝炎患者血清IGF—I、TNF—α水平与脂质过氧化的关系

目的：探讨了慢性丙型肝炎患者血清IGF—I、TNF—α水平与脂质过氧化的关系。方法：应用放免法对32例慢性丙型肝炎患者进行了血清IGF—I、TNF—α水平测定，化学比色法测定丙二醛（MDA）、超氧化物歧化酶（SOD），并与35名正常健康人作比较。结果：慢性丙型肝炎患者血清TNF—α、MDA水平非常显著地高于正常人组（P〈0．01），而IGF—I、SOD水平则非常显著地低于正常人组（P〈0．01），相关分析显示，血清TNF—α与MDA呈正相关（r=0．6012，P〈0．01）。IGF—I与MDA呈负相关（r=-0．4018，P〈0．05）。结论：慢性丙型肝炎患者存在脂质过氧化，与IGF—I和TNF—α存在相关性。

Study on the Relationship Between Serum IGF-I, TNF-α Levels and Lipid Peroxidation in Patients with Chronic Hepatitis

Objective To study the relationship between serum IGF - I, TNF - α levels and lipid peroxidation in patients with chronic hepatitis C. Mothods Serum IGF -I, TNF - α （with RIA） levels as wen as serum MBA, SOD （with CLIA） levels were examined in 32 patients with chronic hepatitis C and 35 controls. Results Serum Levels of IGF - I and MDA were significantly higher in patients with chronic hepatitis C than those in controls （P 〈 0. 01 ）, while the serum levels of IGF - I and SOD were significantly lower （P 〈 0.01 ）. Serum levels of TNF - α were positively correlated with MDA levels （ r = 0. 6012, P 〈 0.01 ）, while IGF - I levels were negatively correlated with MDA levels （r = - 0. 4018, P 〈 0. 05）. Conclusion Lipid pemxidation was present in patients with chronic hepatitis C, with correlated changes of IGF - I and TNF - α levels.