新生儿缺氧缺血性脑病血清NO2／NO3和cGMP的改变

目的研究新生儿缺氧缺血性脑病（HIE）血清一氧化氮（NO）的变化及其临床意义。方法采用镀铜镐还原法和放射免疫法检测48例HIE患者血清NO2／NO3和cGMP的含量。结果新生儿HIE血清中NO2／NO3和cGMP的含量明显高于对照组（P＜0．01），治疗后患者血清中NO2／NO3和cGMP的含量较治疗前明显减低（P＜0．05）。结论NO参与了新生儿HIE的发病过程，检测血清NO的含量有助于判断患者的病情。提示临床开发和应用NO生成抑制剂可能有助于新生HIE的治疗。

Changes of Serum Nitrite/Nitrate and cGMP in Neonatal Hypoxic-ischemic Encephalopathy

To study the changes of serum nitric oxide (NO) content in neonatal hypokic-ischemic encephalopathy (HIE) and its clinical significance. Methods Serum nitrite/nitrate (NO2/NO2) and cyclic guanosine monophosphate (cGMP) in 48 patients were measured with copper-coated cadmium reduction method and radioimmunoassay. Results Serum NO2/NO3 and cGMP in HIE group were significantly higher than those in control group (P<0. 01). After treatment they were lower than those before treatment (P<0. 05).Conclusion NO is involved in the pathophysiology of neonatal HIE. Detecting serum NO content may assist to judge the patient's condition and using NO inhibitor to. decrease the excessive production of NO at early stage may be beneficial to the treatment of HIE.