| 海带多糖的抗辐射作用与脾细胞凋亡 |
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| 引用本文： | 吴晓旻,杨明亮,黄晓兰,阎俊,罗琼. 海带多糖的抗辐射作用与脾细胞凋亡[J]. 武汉大学学报(医学版), 2004, 25(3): 239-241,252 |
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| 作者姓名： | 吴晓旻 杨明亮 黄晓兰 阎俊 罗琼 |
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| 作者单位： | 武汉大学公共卫生学院卫生学教研室,武汉,430071 |
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| 基金项目： | 湖北省科技厅重点攻关项目资助 ( 2 0 0 1AA3 0 7B) |
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| 摘 要： | 目的 :探讨海带多糖 (LJP)抗辐射作用及其可能机理。方法 :将Wistar大鼠随机分为正常对照组、模型组和 4个不同剂量LJP实验组 ,灌胃 1 0d后行一次性γ射线辐射 ,每只 9.0Gy ,1 8h后测定各组大鼠体液免疫、细胞免疫、非特异性免疫相关指标及脾淋巴细胞凋亡率。结果 :模型组免疫指标明显低于正常对照组 ,LJP各组能显著调节辐射损伤大鼠的免疫功能 ,脾淋巴细胞凋亡率显著低于模型组 ,并呈现明显的剂量 效应关系。结论 :LJP抗辐射作用的可能机理之一是抑制免疫细胞凋亡
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| 关 键 词： | 海带多糖 辐射 脾淋巴细胞 凋亡 |
| 文章编号： | 1671-8852(2004)03-0239-04 |
Effect of Laminaria Japonica Polysaccharides on Radioprotection and Splenic Lymphocyte Apoptosis |
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| Wu Xiaomin,Yang Mingliang,Huang Xiaolan,et al Departerment of Hygiene,School of Public Heath,Wuhan University,Wuhan ,China. Effect of Laminaria Japonica Polysaccharides on Radioprotection and Splenic Lymphocyte Apoptosis[J]. Medical Journal of Wuhan University, 2004, 25(3): 239-241,252 |
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| Authors: | Wu Xiaomin Yang Mingliang Huang Xiaolan et al Departerment of Hygiene School of Public Heath Wuhan University Wuhan China |
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| Affiliation: | Wu Xiaomin,Yang Mingliang,Huang Xiaolan,et al Departerment of Hygiene,School of Public Heath,Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective: To investigate radioprotective effect of laminaria japonica polysaccharides (LJP) and its possible mechanism. Methods: The Wistar rats were randomly divided into 6 groups, the normal group, the model group and four LJP treatment groups(100,200,300 and 400 mg·kg -1 ·d -1 ). LJP of four different doses was applied to different group respectively for 10 d before whole body irradiation with γ ray(9.0 Gy). The indexes of humoral immune, cellular immune, nonspecific immune functions and apoptosis ratio of splenic lymphocyte were measured 18 h later. Results: The related immune indexes of the positive control group were obviously lower than those of the normal group.The apoptosis ratio of splenic lymphocyte in the positive control group was higher than that in other groups. LJP significantly modulated immune function in irradiated rat and there was a dose effect relationship in a certain range of dosage. Conclusion: The radioprotective action of LJP is due ,at least in part, to its arrestment of lymphocyte apoptosis. |
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| Keywords: | laminaria japonica polysaccharides irradiation immunoloregulation splenic lymphocyte apoptosis |
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