High Dose Epoetin Beta in the First Weeks Following Renal Transplantation and Delayed Graft Function: Results of the Neo‐PDGF Study |
| |
| Authors: | F. Martinez N. Kamar N. Pallet P. Lang A. Durrbach Y. Lebranchu A. Adem S. Barbier E. Cassuto‐Viguier F. Glowaki Y. Le Meur L. Rostaing C. Legendre O. Hermine G. Choukroun for the NeoPDGF Study Investigators |
| |
| Affiliation: | 1. Service de Transplantation Rénale et Soins Intensifs, H?pital Necker, Assistance Publique H?pitaux de Paris et Université Paris Descartes, Paris, France;2. Service de Néphrologie, Dialyse et Transplantation, CHU Rangueil, Toulouse, France;3. Service de Néphrologie et Transplantation, H?pital Henri Mondor, Assistance Publique H?pitaux de Paris et Université Paris XII, Créteil, France;4. Service de Néphrologie et Transplantation, H?pital de Bicêtre, Assistance Publique H?pitaux de Paris et Université Paris‐Sud, Le Kremlin‐Bicètre, France;5. Service de Néphrologie et d’Immunologie Clinique, H?pital Bretonneau et Université Fran?ois‐Rabelais, Tours, France;6. Urgences Néphrologiques et Transplantation Rénale, H?pital Tenon, Assistance Publique H?pitaux de Paris et Université Paris VI, Paris, France;7. Service de Néphrologie, d’Hémodialyse et de Transplantation Rénale, H?pital de Bois Guillaume et Université de Rouen, Rouen, France;8. Fédération d’Uro‐Néphrologie, H?pital Pasteur et Université de Nice, Nice, France;9. P?le de Néphrologie, CHRU de Lille, Lille, France;10. Service de Néphrologie, CHU de Brest, Brest, France;11. Service d’Hématologie adulte, H?pital Necker, Assistance Publique H?pitaux de Paris, Université Paris Descartes et CNRS UMR 8147, Paris, France;12. Service de Néphrologie, Dialyse, Transplantation et Réanimation, CHU d’Amiens, Université Jules Verne et INSERM ERI‐12, Amiens, France |
| |
| Abstract: | Erythropoietin promotes nephroprotection in animal models of ischemia‐reperfusion injury. Neorecormon® and Prevention of Delayed Graft Function (Neo‐PDGF) is a French open‐label multicenter randomized study to evaluate the effect of high doses of epoetin beta (EPO‐β) during the first 2 weeks of renal transplantation on renal function in patients at risk for delayed graft function (DGF). One hundred and four patients were included in the study. Patients randomized in treatment group (A) received four injections of EPO‐β (30.000 UI each), given before surgery and at 12 h, 7 days and 14 days posttransplantation. Patients randomized in control group (B) did not receive EPO‐β. Immunosuppression included induction with basiliximab and maintenance therapy with steroids, mycophenolate mofetil and tacrolimus. At 1 month posttransplant, the estimated glomerular filtration rate (MDRD formula) was 42.5 ± 19.0 mL/min in the EPO‐β group and 44.0 ± 16.3 mL/min in the control group (p = ns). The frequency of DGF was similar in both groups (32% vs. 38.8%; p = ns). No difference in the incidence of serious adverse events was observed. (ClinicalTrials.gov number, NCT00815867.) |
| |
| Keywords: | Delayed graft function epoetin ischemia‐reperfusion renal transplantation |
|
|
