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ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP‐induced osteoblast differentiation and bone formation |
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| Authors: | Maarten van Dinther Nils Visser David JJ de Gorter Joyce Doorn Marie‐José Goumans Jan de Boer Peter ten Dijke |
| Institution: | 1. Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands;2. Department of Tissue Regeneration, University of Twente, Institute of Biomedical Technology, Enschede, The Netherlands |
| Abstract: | |
| Keywords: | bone morphogenetic protein ectopic bone formation fibrodysplasia ossificans progressiva osteoblast differentiation Smad |