Retinal vascular events after intravitreal bevacizumab |
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| Authors: | Ahmad M Mansour Leon A Bynoe John C Welch Richard Pesavento Padmamalini Mahendradas Focke Ziemssen Sivakami A Pai |
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| Institution: | 1. Department of Ophthalmology, American University of Beirut, Rafic Hariri University Hospital, Beirut, Lebanon;2. Retina Associates of Coral Springs, Coral Springs, Florida, USA;3. Retina Clinic, Hastings, Nebraska, USA;4. Retina Consultants of Southern California, Loma Linda, California, USA;5. Departments of Uveitis and Retina, Narayana Nethralaya, Bangalore, India;6. Tuebingen Bevacizumab Study Group, Department of Ophthalmology, University of Tuebingen, Germany |
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| Abstract: | Acta Ophthalmol. 2010: 88: 730–735 Abstract. Purpose: To record retinal vascular events following intravitreal bevacizumab injection. Methods: Collaborative multi‐centre retrospective case series. Results: Eight patients were documented to have central retinal artery occlusion (four patients), branch retinal artery occlusion, capillary occlusion, central retinal vein occlusion and branch retinal vein occlusion (one patient each) within 0–55 days (median 2 weeks) of intravitreal bevacizumab. All patients had several ocular and systemic risk factors for retinal vascular events: elevated intraocular pressure on discharge (four patients), pre‐existent glaucoma (one patient), pre‐existent ischaemic retinal vascular disorder (four patients), systemic hypertension (five patients), diabetes mellitus (three patients), coronary artery disease (four patients), carotid disease (three patients), smoking (two patients) and migraine (one patient). Conclusion: The retinal vascular events may be associated with the underlying ocular disease under treatment or with the underlying systemic disease, may be related to an increased intraocular pressure post‐injection constraining further an already poor retinal perfusion, the vasoconstrictor effect of bevacizumab, or a combination of all three. |
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| Keywords: | bevacizumab branch retinal artery occlusion branch retinal vein occlusion capillary occlusion central retinal artery occlusion central retinal vein occlusion |
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