Advances in the Genetics of Familial Renal Cancer |
| |
| Authors: | Patrick J Morrison Deirdre E Donnelly A Brew Atkinson Alexander P Maxwell |
| |
| Institution: | 1. aRegional Medical Genetics Centre and;2. bRegional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, United Kingdom;3. cRegional Nephrology Centre, Belfast City Hospital, Belfast, United Kingdom |
| |
| Abstract: | We discuss recent advances in the diagnosis and management of renal cell cancer (RCC) given the enhanced molecular genetics knowledge in this area. A number of hereditary renal cancer syndromes have been described, including von Hippel-Lindau disease, Birt-Hogg-Dubé syndrome, hereditary leiomyomatosis/RCC syndrome, and hereditary papillary renal cancer. Early molecular diagnosis now facilitates the management and prevention of RCC in families. Recommendations for screening in families are discussed. |
| |
| Keywords: | Renal cancer Familial MET Papillary Clear cell |
|
|
